Concepedia

Cas Protein Structure-function Analysis

Cas Protein Structure-Function Analysis is a systematic investigative framework that integrates structural biology and functional genomics to elucidate the mechanistic relationship between the three-dimensional architecture of Cas proteins and their molecular activities in CRISPR-based genome editing systems.

61

Publications

6.4K

Citations

434

Authors

145

Institutions

Publications per year

2017–2026

41

Parents

Publications

61

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

Sergey Shmakov, Omar O. Abudayyeh, Kira S. Makarova et al. · Molecular Cell · 2015 · 1.3K citations · Full text

, , +16

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

Kira S. Makarova, L. Aravind, Yuri I. Wolf et al. · Biology Direct · 2011 · 471 citations · Full text

, , +15

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

Jing Zhang, Christophe Rouillon, Melina Kerou et al. · Molecular Cell · 2012 · 300 citations · Full text

, , +11

Structural basis of CRISPR–SpyCas9 inhibition by an anti-CRISPR protein

De Dong, Minghui Guo, Sihan Wang et al. · Nature · 2017 · 271 citations

, , +13

A dual function of the CRISPR–Cas system in bacterial antivirus immunity and DNA repair

Mohan Babu, Natalia Beloglazova, Robert Flick et al. · Molecular Microbiology · 2010 · 265 citations · Full text

, , +17

1–5 of 61

Authors

434

  1. EV
    Eugene V. Koonin

    National Center for Biotechnology Information, United States

    3 publications · 2K citations

    3

    h-index

  2. HZ
    Heng Zhang

    Peking University, China

    3 publications · 156 citations

    3

    h-index

  3. AK
    Ailong Ke

    Cornell University, United States

    3 publications · 320 citations

    3

    h-index

  4. RN
    Ryan N. Jackson

    Utah State University, United States

    3 publications · 315 citations

    3

    h-index

  5. BW
    Blake Wiedenheft

    Montana State University, United States

    3 publications · 542 citations

    3

    h-index

1–5 of 434

Institutions

145

  1. Chinese Academy of Sciences

    Beijing, China

    8 h-index

    41 publications

    3.7K citations

  2. University of Chinese Academy of Sciences

    Beijing, China

    7 h-index

    22 publications

    1.6K citations

  3. Institute of Biophysics

    Beijing, China

    5 h-index

    26 publications

    2.9K citations

  4. National Institutes of Health

    Bethesda, United States

    5 h-index

    14 publications

    4.1K citations

  5. Lawrence Berkeley National Laboratory

    Berkeley, United States

    4 h-index

    9 publications

    1K citations

  6. University of California, Berkeley

    Berkeley, United States

    4 h-index

    21 publications

    2.6K citations

  7. Cornell University

    Ithaca, United States

    3 h-index

    15 publications

    1.9K citations

  8. Center for Life Sciences

    Beijing, China

    3 h-index

    14 publications

    2.6K citations

1–8 of 145

Venues

  1. Molecular Cell

    7 publications · 2.1K citations

    7

    h-index

  2. Nucleic Acids Research

    7 publications · 220 citations

    7

    h-index

  3. Cell

    4 publications · 631 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 234 citations

    3

    h-index

  5. Nature Chemical Biology

    3 publications · 129 citations

    3

    h-index

1–5