A conformational switch controls hepatitis delta virus ribozyme catalysis

Ailong Ke, Kaihong Zhou, Fang Ding, +2

Nature

Virus StructureViral ReplicationProtein FoldingMolecular BiologyVirology +3

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

Ki Hyun Nam, Charles H. Haitjema, Xueqi Liu, +4

Structure

Rna ProcessingOff-target EffectMedicineNatural SciencesMolecular Biology +8

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Yibei Xiao, Min Luo, Robert P. Hayes, +5

Cell

EngineeringSubstrate Handover MechanismsStructure BasisGenetic EngineeringMolecular Biology +8

Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli

Robert P. Hayes, Yibei Xiao, Fran Ding, +5

Nature

E. ColiStructural BioinformaticsNatural SciencesMedicineMolecular Biology +6

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

Yanwu Huo, Ki Hyun Nam, Fang Ding, +9

Nature Structural & Molecular Biology

ChromatinCascade-activated Dna UnwindingNatural SciencesGenetic EngineeringMolecular Biology +10

Crystal structures of the SAM-III/SMK riboswitch reveal the SAM-dependent translation inhibition mechanism

Changrui Lu, Angela M. Smith, Ryan T. Fuchs, +4

Nature Structural & Molecular Biology

BiochemistryNatural SciencesProtein BiosynthesisRna Structure PredictionProtein X-ray Crystallography +7

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Adam Dolan, Zhonggang Hou, Yibei Xiao, +5

Molecular Cell

Off-target EffectMedicineGeneticsGenetic EngineeringStem Cell Research +7

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

Sandro F. Ataide, N. Schmitz, Kuang Shen, +4

Science

Crystal StructureProtein SecretionEngineeringMolecular BiologyActivated Srp +17

How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration

Yibei Xiao, Sherwin Ng, Ki Hyun Nam, +1

Nature

Type Ii Crispr–casImmunologyGene EditingGenome EditingMedicine +3

Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches

Ian R. Price, Ahmed Gaballa, Fang Ding, +2

Molecular Cell

Mn2+-sensing MechanismsRna BiologyMolecular BiologyMedicineStructural Biology +1