Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Piero Parchi, Armin Giese, Sabina Capellari et al. · Annals of Neurology · 1999 · 1.4K citations

Veterinary Medicine, Genetics, Neurology +17

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +14

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

Stanley B. Prusiner, Michael Scott, Dallas Foster et al. · Cell · 1990 · 869 citations

Life Sciences, Genetics, Molecular Biology +15

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

Richard A. Bessen, Richard F. Marsh · Journal of Virology · 1992 · 447 citations · Full text

Veterinary Medicine, Infectious Diseases, Pathobiology +16

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

M. E. Bruce, I. McConnell, H. Fraser et al. · Journal of General Virology · 1991 · 384 citations

Veterinary Medicine, Genetics, Infectious Diseases +15