Concepedia

Prion Diseases

Prion disease is a transmissible neurodegenerative disorder caused by pathogenic isoforms of prion protein that propagate through neural tissue by inducing conformational misfolding of normal cellular prion protein, resulting in progressive neuronal degeneration and death.

6.5K

Publications

469.5K

Citations

16.3K

Authors

3.1K

Institutions

Publications per year

2017–2026

833

Variants

Prion DisordersTransmissible Spongiform EncephalopathiesTses

Parents

Children

Publications

6.5K

Novel Proteinaceous Infectious Particles Cause Scrapie

Stanley B. Prusiner · Science · 1982 · 5.1K citations

, , +10

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

, , +17

Mice devoid of PrP are resistant to scrapie

Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell · 1993 · 2.1K citations · Full text

, , +8

Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent

M. E. Bruce, Robert Will, James W. Ironside et al. · Nature · 1997 · 2K citations

, , +3

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

John Collinge, Katie Sidle, Julie Meads et al. · Nature · 1996 · 1.7K citations

, , +15

1–5 of 6.5K

Authors

16.3K

  1. SB
    Stanley B. Prusiner

    University of California, San Francisco, United States

    268 publications · 53.9K citations

    124

    h-index

  2. BC
    Byron Caughey

    National Institute of Allergy and Infectious Diseases, United States

    136 publications · 17.9K citations

    72

    h-index

  3. AA
    Adriano Aguzzi

    University Hospital of Zurich, Switzerland

    154 publications · 18.4K citations

    69

    h-index

  4. JC
    John Collinge

    University College London, United Kingdom

    166 publications · 18.8K citations

    69

    h-index

  5. SJ
    Stephen J. DeArmond

    University of California, San Francisco, United States

    102 publications · 17.2K citations

    61

    h-index

1–5 of 16.3K

Institutions

3.1K

  1. University of California, San Francisco

    San Francisco, United States

    136 h-index

    1.6K publications

    316.7K citations

  2. National Institutes of Health

    Bethesda, United States

    87 h-index

    1K publications

    93.6K citations

  3. Case Western Reserve University

    Cleveland, United States

    77 h-index

    1.2K publications

    109.4K citations

  4. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    77 h-index

    770 publications

    88.2K citations

  5. University College London

    London, United Kingdom

    68 h-index

    1.3K publications

    102.8K citations

  6. MRC Prion Unit

    London, United Kingdom

    64 h-index

    1K publications

    94.1K citations

  7. University of Edinburgh

    Edinburgh, United Kingdom

    64 h-index

    762 publications

    52.4K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    62 h-index

    681 publications

    56.2K citations

1–8 of 3.1K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 243 publications · 43.6K citations

    123

    h-index

  2. Journal of Biological Chemistry

    JBC · 296 publications · 26.2K citations

    94

    h-index

  3. Journal of General Virology

    304 publications · 22.9K citations

    87

    h-index

  4. Journal of Virology

    JVI · 280 publications · 23.2K citations

    85

    h-index

  5. PLoS Pathogens

    134 publications · 9.4K citations

    59

    h-index

1–5

See also

Prion Diseases

Molecular Mechanisms

Diagnosis

Transmission Routes

Clinical Variants

Therapeutic Strategies