Concepedia

Structural Polymorphism Of Prions

Structural Polymorphism of Prions is a structural biology phenomenon characterized by the ability of misfolded prion proteins to adopt multiple, self-propagating conformational isoforms that underlie distinct prion strains and their transmission barriers.

422

Publications

41K

Citations

1.7K

Authors

567

Institutions

Publications per year

2017–2026

54

Parents

Publications

422

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Jie Wang, Jeong‐Mo Choi, Alex S. Holehouse et al. · Cell · 2018 · 2.2K citations · Full text

, , +17

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

John Collinge, Katie Sidle, Julie Meads et al. · Nature · 1996 · 1.7K citations

, , +15

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

, , +14

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

Simon Alberti, Randal Halfmann, Oliver D. King et al. · Cell · 2009 · 1K citations · Full text

, , +14

A protease-resistant protein is a structural component of the Scrapie prion

Michael P. McKinley, David C. Bolton, Stanley B. Prusiner · Cell · 1983 · 923 citations · Full text

, , +16

1–5 of 422

Authors

1.7K

  1. SB
    Stanley B. Prusiner

    University of California, San Francisco, United States

    21 publications · 6.2K citations

    19

    h-index

  2. WK
    Witold K. Surewicz

    Case Western Reserve University, United States

    13 publications · 1.2K citations

    13

    h-index

  3. KW
    Kurt Wüthrich

    ETH Zurich, Switzerland

    13 publications · 1.5K citations

    13

    h-index

  4. JS
    Jonathan S. Weissman

    Howard Hughes Medical Institute, United States

    12 publications · 3.5K citations

    12

    h-index

  5. JC
    John Collinge

    University College London, United Kingdom

    11 publications · 2.4K citations

    11

    h-index

1–5 of 1.7K

Institutions

567

  1. University of California, San Francisco

    San Francisco, United States

    32 h-index

    153 publications

    48.1K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    24 h-index

    62 publications

    17.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    22 h-index

    80 publications

    6K citations

  4. Case Western Reserve University

    Cleveland, United States

    20 h-index

    92 publications

    5.9K citations

  5. ETH Zurich

    Zurich, Switzerland

    16 h-index

    66 publications

    8.3K citations

  6. National Institutes of Health

    Bethesda, United States

    15 h-index

    77 publications

    7.8K citations

  7. University of Alberta

    Edmonton, Canada

    11 h-index

    52 publications

    3.4K citations

  8. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    11 h-index

    59 publications

    6.9K citations

1–8 of 567

Venues

  1. Journal of Biological Chemistry

    JBC · 30 publications · 1.6K citations

    23

    h-index

  2. Journal of Molecular Biology

    JMB · 23 publications · 2.3K citations

    22

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.9K citations

    20

    h-index

  4. Cell

    16 publications · 8.7K citations

    16

    h-index

  5. Nature

    16 publications · 7.1K citations

    16

    h-index

1–5