Concepedia

Prion Strain Adaptation

Prion Strain Adaptation is a biological phenomenon in which a prion strain acquires enhanced replication efficiency or altered pathogenic properties upon transmission to a new host species or cellular environment, distinguished from related strain dynamics by its selective optimization to specific host factors through conformational selection.

23

Publications

2.6K

Citations

126

Authors

61

Institutions

Publications per year

2017–2026

8

Parents

Publications

23

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

Heather L. True, Susan Lindquist · Nature · 2000 · 687 citations

, , +16

Darwinian Evolution of Prions in Cell Culture

Jiali Li, Shawn Browning, Anja M. Oelschlegel et al. · Science · 2010 · 434 citations · Full text

, , +16

Prions are a common mechanism for phenotypic inheritance in wild yeasts

Randal Halfmann, Daniel F. Jarosz, Sandra K. Jones et al. · Nature · 2012 · 398 citations

, , +8

Adaptation and Selection of Prion Protein Strain Conformations following Interspecies Transmission of Transmissible Mink Encephalopathy

Jason C. Bartz, Richard A. Bessen, Debbie McKenzie et al. · Journal of Virology · 2000 · 155 citations

, , +15

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

Christopher R. Birkett · The EMBO Journal · 2001 · 150 citations · Full text

, , +8

1–5 of 23

Authors

126

  1. IV
    Ilia V. Baskakov

    University of Maryland, Baltimore, United States

    4 publications · 163 citations

    4

    h-index

  2. SL
    Susan Lindquist

    Howard Hughes Medical Institute, United States

    4 publications · 1.2K citations

    4

    h-index

  3. NM
    Natallia Makarava

    University of Maryland, Baltimore, United States

    3 publications · 113 citations

    3

    h-index

  4. GC
    Glenn C. Telling

    Colorado State University, United States

    3 publications · 249 citations

    3

    h-index

  5. EA
    Edward A. Hoover

    Colorado State University, United States

    2 publications · 163 citations

    2

    h-index

1–5 of 126

Institutions

61

  1. University of Maryland, Baltimore

    Baltimore, United States

    4 h-index

    14 publications

    548 citations

  2. Colorado State University

    Fort Collins, United States

    3 h-index

    27 publications

    2.2K citations

  3. Istituto Superiore di Sanità

    Rome, Italy

    3 h-index

    4 publications

    258 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    4 publications

    1.9K citations

  5. Whitehead Institute for Biomedical Research

    Cambridge, United States

    3 h-index

    12 publications

    2.5K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    4 publications

    91 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    2 publications

    95 citations

  8. University of Toronto

    Toronto, Canada

    2 h-index

    8 publications

    162 citations

1–8 of 61

Venues

  1. PLoS Pathogens

    3 publications · 154 citations

    3

    h-index

  2. Nature

    2 publications · 1.1K citations

    2

    h-index

  3. Prion

    2 publications · 64 citations

    2

    h-index

  4. Journal of Virology

    JVI · 2 publications · 209 citations

    2

    h-index

  5. Journal of Clinical Investigation

    JCI · 1 publications · 42 citations

    1

    h-index

1–5