Concepedia

Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice

Qun Fu, Jing Li, Lili Qiu, Jiaping Ruan, Mingjie Mao, Shu‐Ming Li, Qing-Hong Mao

International Immunopharmacology · 2020 · 56 citations · 39 references

DOI

Concepts

References

39

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.9K citations · Full text

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

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Role of interleukin‐1β in postoperative cognitive dysfunction

Mario Cibelli, António Rei Fidalgo, Niccolò Terrando et al. · Annals of Neurology · 2010 · 743 citations

, , +16

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Hua Jiang, Hongbin He, Yun Chen et al. · The Journal of Experimental Medicine · 2017 · 729 citations · Full text

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Tumor necrosis factor-α triggers a cytokine cascade yielding postoperative cognitive decline

Niccolò Terrando, Claudia Monaco, Daqing Ma et al. · Proceedings of the National Academy of Sciences · 2010 · 728 citations · Full text

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