Jae Jin Chae

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

Somatic Mutations in <i>UBA1</i> and Severe Adult-Onset Autoinflammatory Disease

David B. Beck, Marcela A. Ferrada, Keith A. Sikora et al. · New England Journal of Medicine · 2020 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Geun‐Shik Lee, Naeha Subramanian, Andrew I. Kim et al. · Nature · 2012 · 1.1K citations

Life Sciences, Immunology, Molecular Biology +14

Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Qing Zhou, Dan Yang, Amanda K. Ombrello et al. · New England Journal of Medicine · 2014 · 893 citations · Full text

Life Sciences, Genetics, Neurology +14

De novo <i>CIAS1</i> mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

Ivona Aksentijevich, Miroslawa Nowak, Mustapha Mallah et al. · Arthritis & Rheumatism · 2002 · 703 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17