A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

Marco Tartaglia, Charlotte M. Niemeyer, Alessandra Fragale et al. · Nature Genetics · 2003 · 1K citations

Medicine, Genetics, Molecular Genetics +17

Crystal Structure of the Tyrosine Phosphatase SHP-2

Peter Hof, Scott Pluskey, Sirano Dhe‐Paganon et al. · Cell · 1998 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

Life Sciences, Cell Biology, Oncology +16

Activating Mutations of the Noonan Syndrome-Associated <b> <i>SHP2/PTPN11</i> </b> Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

Mohamed Bentires‐Alj, J. Guillermo Paez, Frank David et al. · Cancer Research · 2004 · 513 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Dietrich Alexander Ruess, Guus J.J.E. Heynen, Katrin J. Ciecielski et al. · Nature Medicine · 2018 · 373 citations

Medicine, Molecular Biology, Oncology +14