Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg et al. · Nature Genetics · 2001 · 1.7K citations

Life Sciences, Genetics, Molecular Genetics +11

Crystal Structure of the Tyrosine Phosphatase SHP-2

Peter Hof, Scott Pluskey, Sirano Dhe‐Paganon et al. · Cell · 1998 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

Marco Tartaglia, Kamini Kalidas, Adam Shaw et al. · The American Journal of Human Genetics · 2002 · 797 citations · Full text

Life Sciences, Genetics, Molecular Genetics +9

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

Gideon Bollag, D. Wade Clapp, Shane Shih et al. · Nature Genetics · 1996 · 608 citations

Medicine, Hematology, Molecular Genetics +13

Hypertelorism With Turner Phenotype

Jacqueline A. Noonan · American journal of diseases of children · 1968 · 543 citations

Life Sciences, Genetics, Molecular Genetics +11