Guus J.J.E. Heynen

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Chong Sun, Liqin Wang, Sidong Huang et al. · Nature · 2014 · 910 citations · Full text

Medicine, Molecular Biology, Oncology +11

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Dietrich Alexander Ruess, Guus J.J.E. Heynen, Katrin J. Ciecielski et al. · Nature Medicine · 2018 · 373 citations

Medicine, Molecular Biology, Oncology +14

Reduced <i>NF1</i> Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Elza C. de Bruin, Catherine Cowell, Patricia H. Warne et al. · Cancer Discovery · 2014 · 209 citations · Full text

Medicine, Oncology, Pharmacology +17

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano et al. · Cell Reports · 2015 · 177 citations · Full text

Medicine, Cancer Biology, Oncology +17

Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors

Giovanni Valenti, Hazel M. Quinn, Guus J.J.E. Heynen et al. · Cancer Research · 2017 · 172 citations

Medicine, Cancer Biology, Oncology +17