Concepedia

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Peter S. Dragovich, Pragya Adhikari, Robert A. Blake, Nicole Blaquière, Jinhua Chen, Yun‐Xing Cheng, Willem den Besten, Jinping Han, Steven J. Hartman, Jintang He,

Bioorganic & Medicinal Chemistry Letters · 2019 · 109 citations · 41 references

DOI

Concepts

References

41

Phthalimide conjugation as a strategy for in vivo target protein degradation

Georg E. Winter, Dennis L. Buckley, Joshiawa Paulk et al. · Science · 2015 · 1.7K citations

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

, , +16

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

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Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

Kevin J. Hamblett, Peter D. Senter, Dana F. Chace et al. · Clinical Cancer Research · 2004 · 1.2K citations

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Development of potent monoclonal antibody auristatin conjugates for cancer therapy

Svetlana O. Doronina, Brian E. Toki, Michael Torgov et al. · Nature Biotechnology · 2003 · 1.2K citations

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