Willem den Besten

Catalytic in vivo protein knockdown by small-molecule PROTACs

Daniel P. Bondeson, Alina Mares, Ian E. Smith et al. · Nature Chemical Biology · 2015 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +9

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

Senthil K. Radhakrishnan, Willem den Besten, Raymond J. Deshaies · eLife · 2014 · 218 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

Mei-Ling Kuo, Willem den Besten, David Bertwistle et al. · Genes & Development · 2004 · 206 citations · Full text

Life Sciences, Cell Biology, Oncology +15

Cytokine-dependent imatinib resistance in mouse BCR-ABL⁺, <i>Arf</i>-null lymphoblastic leukemia

Richard T. Williams, Willem den Besten, Charles J. Sherr · Genes & Development · 2007 · 175 citations · Full text

Medicine, Hematology, Oncology +17

Control of Spermatogenesis in Mice by the Cyclin D-Dependent Kinase Inhibitors p18 ^Ink4c and p19 ^Ink4d

Frédérique Zindy, Willem den Besten, Bo Chen et al. · Molecular and Cellular Biology · 2001 · 122 citations · Full text

Medicine, Cell Biology, Genetics +17