Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

The limited in vitro lifetime of human diploid cell strains

Leonard Hayflick · Experimental Cell Research · 1965 · 5.8K citations

Biology, Human Cell, Cell Division +6

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Lifespan Extension, Aging, Rapamycin Fed +11

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Remi-Martin Laberge, Yu Sun, Arturo V. Orjalo et al. · Nature Cell Biology · 2015 · 1.1K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +8

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Richard A. Miller, Clinton M. Astle, Joseph A. Baur et al. · The Journals of Gerontology Series A · 2010 · 893 citations · Full text

Lifespan Extension, Aging, Ppm Food +15

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo et al. · Nature Communications · 2018 · 553 citations · Full text

Hypertension, Cardiometabolic Risk, Chronic Nr Supplementation +22