Concepedia

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors

Romeo Romagnoli, Paola Oliva, María Kimatrai Salvador, M. Encarnación Camacho, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Roberto Ronca, Elisabetta Grillo,

European Journal of Medicinal Chemistry · 2019 · 37 citations · 48 references

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48

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

Naoufal Zamzami, Philippe Marchetti, Maria Castedo et al. · The Journal of Experimental Medicine · 1995 · 1.6K citations · Full text

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Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz, Saritha Kusam, Cynthia Lam et al. · Nature · 2011 · 810 citations

, , +7

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 789 citations

, , +11

Superoxide in Apoptosis

Jiyang Cai, Dean P. Jones · Journal of Biological Chemistry · 1998 · 762 citations · Full text

, , +17

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin

Chii M. Lin, Holly H. Ho, George R. Pettit et al. · Biochemistry · 1989 · 414 citations

, , +17