Direct measurement of deubiquitinating enzyme activity in intact cells using a protease-resistant, cell-permeable, peptide-based reporter

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

Dharminder Chauhan, Ze Tian, Benjamin Nicholson et al. · Cancer Cell · 2012 · 581 citations

Medicine, Molecular Biology, Oncology +17

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Pádraig D’Arcy, Slavica Brnjic, Maria Hägg Olofsson et al. · Nature Medicine · 2011 · 497 citations · Full text

Life Sciences, Molecular Biology, Oncology +14

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Ze Tian, Pádraig D’Arcy, Xin Wang et al. · Blood · 2013 · 312 citations · Full text

Medicine, Molecular Biology, Oncology +17

Activation Method to Prepare a Highly Reactive Acylsulfonamide “Safety-Catch” Linker for Solid-Phase Synthesis¹

Bradley J. Backes, Alex A. Virgilio, Jonathan A. Ellman · Journal of the American Chemical Society · 1996 · 253 citations

Natural Sciences, Chemistry, Physical Chemistry +6

Kinetic and Mechanistic Studies on the Hydrolysis of Ubiquitin C-Terminal 7-Amido-4-Methylcoumarin by Deubiquitinating Enzymes

Luan C. Dang, Francesco Melandri, Ross L. Stein · Biochemistry · 1998 · 235 citations

Life Sciences, Biochemistry, Molecular Biology +17