Pádraig D’Arcy

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Pádraig D’Arcy, Slavica Brnjic, Maria Hägg Olofsson et al. · Nature Medicine · 2011 · 493 citations

Proteasome Deubiquitinating Activity, Oncology, Medicine +10

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

Ze Tian, Pádraig D’Arcy, Xin Wang et al. · Blood · 2013 · 310 citations · Full text

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Xiaonan Zhang, Mårten Fryknäs, E Hernlund et al. · Nature Communications · 2014 · 247 citations · Full text

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

Xiaonan Zhang, Karthik Selvaraju, Amir Ata Saei et al. · Biochimie · 2019 · 162 citations

Biochemistry, Medicine, Natural Sciences +6

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Xin Wang, Magdalena Mazurkiewicz, Ellin‐Kristina Hillert et al. · Scientific Reports · 2016 · 150 citations · Full text