Concepedia

Enhancing gene editing specificity by attenuating DNA cleavage kinetics

Jeffrey C. Miller, Deepak P. Patil, Danny F. Xia, Charles B. Paine, Friedrich Fauser, Hunter W. Richards, David A. Shivak, Yuri R. Bendaña, Sarah J. Hinkley, Nicholas A. Scarlott,

Nature Biotechnology · 2019 · 64 citations · 55 references

DOI

Concepts

References

55

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.6K citations

, , +17

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell · 2013 · 3.4K citations · Full text

, , +16

In vivo genome editing using Staphylococcus aureus Cas9

F. Ann Ran, Le Cong, Winston X. Yan et al. · Nature · 2015 · 2.7K citations · Full text

, , +11

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text

, , +14

Rationally engineered Cas9 nucleases with improved specificity

Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations

, , +15