Concepedia

Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase

Yoshikazu Iwasawa, Masahiro Hayashi, Takashi Nomoto, Jun Shibata, Morihiro Mitsuya, Kenj Hirota, Mari Yonemoto, Toshio Kamei, Keiko Miura, Koji Tomimoto

Bioorganic & Medicinal Chemistry Letters · 1995 · 20 citations · 13 references

DOI

Concepts

References

13

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

James D. Bergstrom, Marc M. Kurtz, Deborah J. Rew et al. · Proceedings of the National Academy of Sciences · 1993 · 335 citations

, , +12

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Dilip Amin, SA Cornell, SK Gustafson et al. · Journal of Lipid Research · 1992 · 283 citations · Full text

, , +14

Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.

A.J. Baxter, Barbara Fitzgerald, Julie L. Hutson et al. · Journal of Biological Chemistry · 1992 · 209 citations · Full text

, , +16

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

Carl P. Ciosek, David R. Magnin, Thomas Harrity et al. · Journal of Biological Chemistry · 1993 · 102 citations · Full text

, , +16

The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction

Scott A. Biller, Michael J. Sofia, Barbara DeLange et al. · Journal of the American Chemical Society · 1991 · 76 citations

, , +10