Michael J. Sofia

Discovery of a β-<scp>d</scp>-2′-Deoxy-2′-α-fluoro-2′-β-<i>C</i>-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

Michael J. Sofia, Donghui Bao, Wonsuk Chang et al. · Journal of Medicinal Chemistry · 2010 · 613 citations

Viral Polymerase Structure, Hepatitis C Virus, Molecular Biology +18

Structural basis for RNA replication by the hepatitis C virus polymerase

T.C. Appleby, Jason K. Perry, Eisuke Murakami et al. · Science · 2015 · 344 citations

Viral Replication, Rna Replication, Viral Polymerase Structure +19

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Eisuke Murakami, Tatiana Tolstykh, Haiying Bao et al. · Journal of Biological Chemistry · 2010 · 288 citations · Full text

Biochemistry, First Step, Viral Hepatitis +15

Synthesis of Diastereomerically Pure Nucleotide Phosphoramidates

Bruce S. Ross, P. Ganapati Reddy, Hai‐Ren Zhang et al. · The Journal of Organic Chemistry · 2011 · 145 citations

PSI-7851, a Pronucleotide of β- <scp>d</scp> -2′-Deoxy-2′-Fluoro-2′- <i>C</i> -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

Angela M. Lam, Eisuke Murakami, Christine Espiritu et al. · Antimicrobial Agents and Chemotherapy · 2010 · 139 citations · Full text