Christine Espiritu

Discovery of a β-<scp>d</scp>-2′-Deoxy-2′-α-fluoro-2′-β-<i>C</i>-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

Michael J. Sofia, Donghui Bao, Wonsuk Chang et al. · Journal of Medicinal Chemistry · 2010 · 620 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Eisuke Murakami, Tatiana Tolstykh, Haiying Bao et al. · Journal of Biological Chemistry · 2010 · 293 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

Angela M. Lam, Christine Espiritu, Shalini Bansal et al. · Antimicrobial Agents and Chemotherapy · 2012 · 241 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

Klaus Klumpp, Angela M. Lam, Christine Lukacs et al. · Proceedings of the National Academy of Sciences · 2015 · 152 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

PSI-7851, a Pronucleotide of β- <scp>d</scp> -2′-Deoxy-2′-Fluoro-2′- <i>C</i> -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

Angela M. Lam, Eisuke Murakami, Christine Espiritu et al. · Antimicrobial Agents and Chemotherapy · 2010 · 140 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17