Christine Lukacs

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Piro Lito, Anna Saborowski, Jingyin Yue et al. · Cancer Cell · 2014 · 312 citations · Full text

Medicine, Cancer Biology, Oncology +14

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

An Ding, Jessica L. Schneller, Andrea Frassetto et al. · Cell Reports · 2017 · 260 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +16

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

Bradford Graves, Thelma Thompson, Mingxuan Xia et al. · Proceedings of the National Academy of Sciences · 2012 · 227 citations · Full text

Medicine, Cancer Biology, Oncology +14

Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

Lei Jiang, Pedro Berraondo, Daniel Jericó et al. · Nature Medicine · 2018 · 180 citations · Full text

Life Sciences, Molecular Biology, Molecular Medicine +8