CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

Álvaro Teijeira, Saray Garasa, María Gato, +23

Immunity

InflammationCytokineImmune CytotoxicityGranulocyteImmunology +6

Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma

Kurt A. Schalper, María E. Rodríguez-Ruiz, Ricardo Díez-Valle, +17

Nature Medicine

Neuro-oncologyCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +9

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

Elísabeth Pérez-Ruiz, Luna Minute, Itziar Otano, +14

Nature

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

Carlos Alfaro, Álvaro Teijeira, Carmen Oñate, +17

Clinical Cancer Research

Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

Lei Jiang, Pedro Berraondo, Daniel Jericó, +20

Nature Medicine

Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration

Gloria Álvarez‐Sola, Iker Uriarte, María U. Latasa, +19

Gut

Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma

Iñigo Tirapu, Eduardo Huarte, Cristiana Guiducci, +11

Cancer Research

T-regulatory CellImmunologyPathologyImmunologic MechanismImmune System +16

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

María E. Rodríguez-Ruiz, José Luis Perez‐Gracia, Inmaculada Rodríguez, +17

Annals of Oncology

Intratumor Adoptive Transfer of IL-12 mRNA Transiently Engineered Antitumor CD8+ T Cells

Iñaki Etxeberría, Elixabet Bolaños, José I. Quetglas, +22

Cancer Cell

Cell TherapyIl-12 MrnaCancer ImmunosurveillanceMedicineImmunology +5

Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice

Manuela González-Aparicio, Pilar Alzuguren, Itsaso Mauleón, +8

Gut