Concepedia

Wonsuk Chang

WC

26

Publications

2.7K

Citations

22

H-Index

2001

Active since

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)(Current)

PharmaSeq (United States)

Johns Hopkins University

Princeton University

United States Military Academy

Wonsuk Chang is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in medicine, pharmacology, and drug discovery.

Top concepts

MedicinePharmacologyDrug DiscoveryBiochemistryNatural SciencesMolecular BiologyHepatitisImmunologyChemistryViral Hepatitis

Publications per year

2001–2024

26

Publications

26

Discovery of a β-<scp>d</scp>-2′-Deoxy-2′-α-fluoro-2′-β-<i>C</i>-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

Michael J. Sofia, Donghui Bao, Wonsuk Chang et al. · Journal of Medicinal Chemistry · 2010 · 613 citations

Viral Polymerase Structure, Hepatitis C Virus, Molecular Biology +18

An orally available non-nucleotide STING agonist with antitumor activity

Bo‐Sheng Pan, Samanthi A. Perera, Jennifer Piesvaux et al. · Science · 2020 · 609 citations

Antitumor Activity, Immunology, Immunoediting +19

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Eisuke Murakami, Tatiana Tolstykh, Haiying Bao et al. · Journal of Biological Chemistry · 2010 · 288 citations · Full text

Biochemistry, First Step, Viral Hepatitis +15

A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen et al. · Nature · 2022 · 125 citations

Signal Transduction, Biochemistry, Receptor Tyrosine Kinase +5

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer

Wonsuk Chang, Michael D. Altman, Charles A. Lesburg et al. · Journal of Medicinal Chemistry · 2022 · 122 citations · Full text

Immunology, Molecular Biology, Interferon Genes +17

Rows per page

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