Concepedia

Charles A. Lesburg

CA

44

Publications

2.8K

Citations

25

H-Index

1995

Active since

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)(Current)

Quantitative BioSciences

University of Pennsylvania

WuXi AppTec (China)

Charles A. Lesburg is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in drug discovery, medicine, and pharmacology.

ORCID

Top concepts

Publications per year

1995–2022

44

Publications

44

An orally available non-nucleotide STING agonist with antitumor activity

Bo‐Sheng Pan, Samanthi A. Perera, Jennifer Piesvaux et al. · Science · 2020 · 609 citations

, , +19

Crystal Structure of Pentalenene Synthase: Mechanistic Insights on Terpenoid Cyclization Reactions in Biology

Charles A. Lesburg, Guangzhi Zhai, David E. Cane et al. · Science · 1997 · 451 citations

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING

Tony Siu, Michael D. Altman, Gretchen A. Baltus et al. · ACS Medicinal Chemistry Letters · 2018 · 163 citations · Full text

A kinase-cGAS cascade to synthesize a therapeutic STING activator

John A. McIntosh, Zhijian Liu, Brian M. Andresen et al. · Nature · 2022 · 125 citations

, , +5

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer

Wonsuk Chang, Michael D. Altman, Charles A. Lesburg et al. · Journal of Medicinal Chemistry · 2022 · 122 citations · Full text

, , +17

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