Angela M. Lam

Discovery of a β-<scp>d</scp>-2′-Deoxy-2′-α-fluoro-2′-β-<i>C</i>-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

Michael J. Sofia, Donghui Bao, Wonsuk Chang et al. · Journal of Medicinal Chemistry · 2010 · 613 citations

Viral Polymerase Structure, Hepatitis C Virus, Molecular Biology +18

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

Eisuke Murakami, Tatiana Tolstykh, Haiying Bao et al. · Journal of Biological Chemistry · 2010 · 288 citations · Full text

Biochemistry, First Step, Viral Hepatitis +15

Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus

Angela M. Lam, Christine Espiritu, Shalini Bansal et al. · Antimicrobial Agents and Chemotherapy · 2012 · 240 citations · Full text

Hepatitis C Virus, Genetics, Molecular Biology +19

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

Klaus Klumpp, Angela M. Lam, Christine Lukacs et al. · Proceedings of the National Academy of Sciences · 2015 · 151 citations · Full text

Crystal Structure, Viral Replication, Hbv Core Protein +18

PSI-7851, a Pronucleotide of β- <scp>d</scp> -2′-Deoxy-2′-Fluoro-2′- <i>C</i> -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

Angela M. Lam, Eisuke Murakami, Christine Espiritu et al. · Antimicrobial Agents and Chemotherapy · 2010 · 139 citations · Full text