Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure

Nobuhiko Kawanishi, T Sugimoto, Jun Shibata, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNatural SciencesRational Drug DesignStructure-based Drug Design +8

An enantioselective synthesis of the A-ring synthon for vitamin D3 metabolites by chemicoenzymatic approach

Susumu Kobayashi, Jun Shibata, Mitsuyuki Shimada, +1

Tetrahedron Letters

A-ring SynthonBiochemistryNatural SciencesVitamin D3 MetabolitesOrganic Chemistry +6

An Effective Method for the Preparation of Chiral Polyoxy 8-Membered Ring Enone Corresponding to the B Ring of Taxol

Isamu Shiina, Jun Shibata, Ryoutarou Ibuka, +2

Bulletin of the Chemical Society of Japan

EngineeringAldehyde 3Active Trioxy AldehydeHeterocyclicEffective Method +9

Spectral Tuning in Sensory Rhodopsin I from Salinibacter ruber

Yuki Sudo, Yasufumi Yuasa, Jun Shibata, +2

Journal of Biological Chemistry

Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9

Tadashi Shimamura, Jun Shibata, Hideki Kurihara, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +9

A New Class of Highly Potent Farnesyl Diphosphate-Competitive Inhibitors of Farnesyltransferase

Tetsuya Aoyama, Toshihiko Satoh, Mari Yonemoto, +13

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceAltmetric Attention ScorePharmacotherapyChemical Biology +16

Preparation of 2,5-bis(diarylmethylene)-2,5-dihydrothiophenes and their furan, selenophene, and N-methylpyrrole analogs

Akihiko Ishii, Yasuaki HORIKAWA, Ikuo Takaki, +3

Tetrahedron Letters

Chemical EngineeringEngineeringOrganic ChemistryChemistryHeterocycle Chemistry +2

Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase

Yoshikazu Iwasawa, Masahiro Hayashi, Takashi Nomoto, +7

Bioorganic & Medicinal Chemistry Letters

Biological ActivityBiosynthesisBiochemistryPotent InhibitorSqualene Synthase +7

J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs

Yoshikazu Iwasawa, Jun Shibata, Morihiro Mitsuya, +7

Bioorganic & Medicinal Chemistry Letters

OxysterolBiochemistrySqualene SynthaseMedicinePharmacotherapy +6

Stereoselective synthesis of J-104,118 and J-104,123, novel, potent inhibitors of squalene synthase

Yoshikazu Iwasawa, Jun Shibata, Katsumasa Nonoshita, +3

Tetrahedron

Medicinal ChemistryBiosynthesisBiochemistrySqualene SynthaseNatural Sciences +9