Nobuhiko Kawanishi

MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel

Toshiyasu Shimomura, Shinichi Hasako, Yoko Nakatsuru et al. · Molecular Cancer Therapeutics · 2010 · 118 citations · Full text

A Novel Approach for the Development of Selective Cdk4 Inhibitors:  Library Design Based on Locations of Cdk4 Specific Amino Acid Residues

Teruki Honma, Takashi Yoshizumi, Noriaki Hashimoto et al. · Journal of Medicinal Chemistry · 2001 · 107 citations · Full text

Atp Binding Pocket, Biomolecular Structure Prediction, Novel Approach +19

Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure

Nobuhiko Kawanishi, T Sugimoto, Jun Shibata et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 101 citations · Full text

Medicinal Chemistry, Medicine, Natural Sciences +10

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

Hiroshi Hirai, Toshiyasu Shimomura, Makiko Kobayashi et al. · Cell Cycle · 2010 · 29 citations · Full text

Chemoprevention Strategy, Immunology, Pharmacotherapy +18

Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo

Hiroshi Hirai, Ikuko Takahashi-Suziki, Toshiyasu Shimomura et al. · Investigational New Drugs · 2010 · 18 citations

Medicinal Chemistry, Oncology, Potent Anti-tumor Activity +7