Takashi Yoshizumi

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 550 citations

Life Sciences, Molecular Biology, Pharmacology +17

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

Hiroshi Hirai, Tsuyoshi Arai, Megumu Okada et al. · Cancer Biology & Therapy · 2010 · 236 citations · Full text

Medicine, Oncology, Pharmacology +17

Asymmetric hydrogenation of cycloalkanones catalyzed by BINAP-iridium(I)-aminophosphine systems

Xiaoyong Zhang, T. TAKETOMI, Takashi Yoshizumi et al. · Journal of the American Chemical Society · 1993 · 110 citations

Natural Sciences, Biochemistry, Chemistry +10

A Novel Approach for the Development of Selective Cdk4 Inhibitors:  Library Design Based on Locations of Cdk4 Specific Amino Acid Residues

Teruki Honma, Takashi Yoshizumi, Noriaki Hashimoto et al. · Journal of Medicinal Chemistry · 2001 · 108 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structures of the PKC-ι kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533–551 in the C-terminal tail and their roles in ATP binding

Tetsuo Takimura, Kenji Kamata, Kazuhiro Fukasawa et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 49 citations

Life Sciences, Biochemistry, Molecular Biology +14