Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada, +20

Molecular Cancer Therapeutics

Wee1 KinaseOncogenic AgentMedicineTyrosine KinaseReceptor Tyrosine Kinase +13

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

Hiroshi Hirai, Tsuyoshi Arai, Megumu Okada, +10

Cancer Biology & Therapy

Antihypertensive effect of a newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model

Masaru Nishikibe, Sonoko Tsuchida, Megumu Okada, +5

Life Sciences

HypertensionGenetic Hypertensive ModelEndothelin AntagonistMedicinePhysiology +6

Role of sulfhydryls in mucosal injury caused by ethanol: relation to microvascular permeability, gastric motility and cytoprotection.

Koji Takeuchi, Megumu Okada, Hiromichi Niida, +1

Journal of Pharmacology and Experimental Therapeutics

Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats

Megumu Okada, Hiromichi Niida, Koji Takeuchi, +1

Digestive Diseases and Sciences

InflammationGastrointestinal PharmacologyMedicineGastric LesionsPathogenetic Mechanism +6

Pathophysiological Roles of Endothelin-1 in Dahl Salt-Sensitive Hypertension

Takanori Ikeda, Hisashi Ohta, Megumu Okada, +7

Hypertension

HypertensionRenal FunctionMolecular PhysiologyCardiovascular DiseaseSalt Intake +12

A continuous monitoring of mucosal integrity and secretory activity in rat stomach: A preparation using a lucite chamber.

Koji Takeuchi, Yasunobu Ishihara, Megumu Okada, +2

The Japanese Journal of Pharmacology

Lucite ChamberMucosal IntegrityGastroenterologyDigestive TractGastrointestinal Peptide Hormone +15

Bilateral adrenalectomy worsens gastric mucosal lesions induced by indomethacin in the rat

Koji Takeuchi, Hideyuki Nishiwaki, Megumu Okada, +2

Gastroenterology

Bilateral AdrenalectomyGastric Mucosal LesionsGastroenterologySurgeryUpper Gastrointestinal Surgery +2

Pharmacological Properties of J-104132 (L-753,037), a Potent, Orally Active, Mixed ETA/ETB Endothelin Receptor Antagonist

M. Nishikibe, Hisashi Ohta, Megumu Okada, +20

Journal of Pharmacology and Experimental Therapeutics

Increased Microvascular Permeability and Lesion Formation During Gastric Hypermotility Caused by Indomethacin and 2-Deoxy-D-Glucose in the Rat

Koji Takeuchi, Megumu Okada, Satomi Ebara, +1

Journal of Clinical Gastroenterology

Vascular PermeabilityGastric HypermotilityMicrovascular PermeabilityGastrointestinal PharmacologyMedicine +9