Tsuyoshi Arai

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 550 citations

Life Sciences, Molecular Biology, Pharmacology +17

<i>Mmh</i> / <i>Ogg1</i> gene inactivation results in accumulation of 8-hydroxyguanine in mice

Osamu Minowa, Tsuyoshi Arai, Masanori Hirano et al. · Proceedings of the National Academy of Sciences · 2000 · 345 citations · Full text

Pharmacy, Genetics, Molecular Genetics +17

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

Hiroshi Hirai, Tsuyoshi Arai, Megumu Okada et al. · Cancer Biology & Therapy · 2010 · 236 citations · Full text

Medicine, Oncology, Pharmacology +17

Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine

Kenjiro Asagoshi, Takao Yamada, Hiroaki Terato et al. · Journal of Biological Chemistry · 2000 · 115 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9

The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA

Tsuyoshi Arai, Vincent P. Kelly, Osamu Minowa et al. · Toxicology · 2006 · 71 citations

Medicine, Molecular Biology, Oncology +12