Hiroshi Hirai

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 550 citations

Life Sciences, Molecular Biology, Pharmacology +17

TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma

Lipika Goyal, Lei Shi, Leah Y. Liu et al. · Cancer Discovery · 2019 · 371 citations · Full text

Medicine, Oncology, Pharmacology +17

Social Participation and the Prevention of Functional Disability in Older Japanese: The JAGES Cohort Study

Satoru Kanamori, Yuko Kai, Jun Aida et al. · PLoS ONE · 2014 · 357 citations · Full text

Nursing, Health Sciences, Disability +13

MK-1775, a Potent Wee1 Inhibitor, Synergizes with Gemcitabine to Achieve Tumor Regressions, Selectively in p53-Deficient Pancreatic Cancer Xenografts

N.V. Rajeshkumar, Elizabeth De Oliveira, Niki A. Ottenhof et al. · Clinical Cancer Research · 2011 · 279 citations · Full text

Medicine, Oncology, Pharmacology +16

Association Between Self-Reported Dental Health Status and Onset of Dementia

Tatsuo Yamamoto, Katsunori Kondo, Hiroshi Hirai et al. · Psychosomatic Medicine · 2012 · 238 citations

Dentistry, Dental Public Health, Dementia +12