Yoshikazu Iwasawa

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 550 citations

Life Sciences, Molecular Biology, Pharmacology +17

MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil

Hiroshi Hirai, Tsuyoshi Arai, Megumu Okada et al. · Cancer Biology & Therapy · 2010 · 236 citations · Full text

Medicine, Oncology, Pharmacology +17

Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist:  1-[(3<i>R</i>,4<i>R</i>)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2<i>H</i>-benzimidazol-2-one (J-113397)

Hiroshi Kawamoto, Satoshi Ozaki, Yoshiki Itoh et al. · Journal of Medicinal Chemistry · 1999 · 204 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors:  New<i>de Novo</i>Design Strategy and Library Design

Teruki Honma, Kyoko Hayashi, Tetsuya Aoyama et al. · Journal of Medicinal Chemistry · 2001 · 200 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist

Satoshi Ozaki, Hiroshi Kawamoto, Yoshiki Itoh et al. · European Journal of Pharmacology · 2000 · 167 citations

Medicine, Medicinal Chemistry, Pharmacology +7