In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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ORL1, a novel member of the opioid receptor family

Catherine Mollereau, Marc Parmentier, Pierre Mailleux et al. · FEBS Letters · 1994 · 1.1K citations

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S.E. Laursen, John K. Belknap · Journal of Pharmacological Methods · 1986 · 391 citations

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