Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada, +20

Molecular Cancer Therapeutics

Wee1 KinaseOncogenic AgentMedicineTyrosine KinaseReceptor Tyrosine Kinase +13

Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors:  New<i>de Novo</i>Design Strategy and Library Design

Teruki Honma, Kyoko Hayashi, Tetsuya Aoyama, +11

Journal of Medicinal Chemistry

Drug TargetBiomolecular Structure PredictionMolecular BiologyChemical BiologyMolecular Design +20

A Novel Approach for the Development of Selective Cdk4 Inhibitors:  Library Design Based on Locations of Cdk4 Specific Amino Acid Residues

Teruki Honma, Takashi Yoshizumi, Noriaki Hashimoto, +10

Journal of Medicinal Chemistry

Atp Binding PocketBiomolecular Structure PredictionNovel ApproachMolecular BiologyLead Identification +17

Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein

Mari Ikuta, Kenji Kamata, Kazuhiro Fukasawa, +6

Journal of Biological Chemistry

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

Tomoko Yoshinari, Mitsuru Ohkubo, Kazuhiro Fukasawa, +7

PubMed

Molecular BiologyPharmacotherapyAntimicrobial ChemotherapyChemical BiologyCulture Medium +14

Structures of the PKC-ι kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533–551 in the C-terminal tail and their roles in ATP binding

Tetsuo Takimura, Kenji Kamata, Kazuhiro Fukasawa, +6

Acta Crystallographica Section D Biological Crystallography

Protein AssemblyC-terminal TailMolecular BiologyAtp BindingChemical Biology +18

Intercalation into DNA is not required for inhibition of topoisomerase I by indolocarbazole antitumor agents.

Christian Bailly, Laurent Dassonneville, Pierre Colson, +4

PubMed

Drug TargetMolecular BiologyPharmacotherapyIndolocarbazole Antitumor AgentsPotent Topoisomerase +15

Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro

Tohru Takaki, Kazuhiro Fukasawa, Ikuko Suzuki‐Takahashi, +1

Biochemical and Biophysical Research Communications

Signal TransductionSignaling PathwayCellular BiochemistryCdk-mediated PhosphorylationMedicine +3

Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo

Hiroshi Hirai, Toshiyasu Shimomura, Makiko Kobayashi, +15

Cell Cycle

Chemoprevention StrategyImmunologyPharmacotherapyCell CycleCancer Biology +16

Sequence-selective DNA cleavage by a topoisomerase I poison, NB-506

Kazuhiro Fukasawa, Hideya Komatani, Yoshikazu Hara, +4

International Journal of Cancer

ChromatinDna SequencingBiochemistryNb-506-selective SitesNatural Sciences +8