Kazuhiro Fukasawa

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

Hiroshi Hirai, Yoshikazu Iwasawa, Megumu Okada et al. · Molecular Cancer Therapeutics · 2009 · 540 citations

Wee1 Kinase, Oncogenic Agent, Medicine +15

Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors:  New<i>de Novo</i>Design Strategy and Library Design

Teruki Honma, Kyoko Hayashi, Tetsuya Aoyama et al. · Journal of Medicinal Chemistry · 2001 · 200 citations · Full text

Drug Target, Biomolecular Structure Prediction, Molecular Biology +22

A Novel Approach for the Development of Selective Cdk4 Inhibitors:  Library Design Based on Locations of Cdk4 Specific Amino Acid Residues

Teruki Honma, Takashi Yoshizumi, Noriaki Hashimoto et al. · Journal of Medicinal Chemistry · 2001 · 107 citations · Full text

Atp Binding Pocket, Biomolecular Structure Prediction, Novel Approach +19

Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein

Mari Ikuta, Kenji Kamata, Kazuhiro Fukasawa et al. · Journal of Biological Chemistry · 2001 · 99 citations · Full text

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

Tomoko Yoshinari, Mitsuru Ohkubo, Kazuhiro Fukasawa et al. · PubMed · 1999 · 62 citations

Molecular Biology, Pharmacotherapy, Antimicrobial Chemotherapy +16