Concepedia

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Kenji Kawada, Akinori Arimura, Tatsuo Tsuri, Masahiro Fuji, Tadafumi Komurasaki, Shuji Yonezawa, Akira Kugimiya, Nobuhiro Haga, Susumu Mitsumori, Masanao Inagaki,

Angewandte Chemie International Edition · 1998 · 41 citations · 0 references

DOI

Concepts

PharmacyImmunologyMedicinal ChemistryImmunopharmacologyMonoclonal AntibodiesSynthetic Medicinal ChemistryRetrosynthetic AnalysisNatural Product Total SynthesisRing-forming ReactionsTotal Synthesis-derived Analogues

Abstract

Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it possible to prepare 1 efficiently and in large quantity.