Publication | Closed Access
Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant
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1998
Year
Proper LinkageImmunologyOrganic ChemistryChemistryHeterocycle ChemistryImmunotherapyMedicinal ChemistryHighly PotentImmunochemistryAntibody EngineeringRegioselective HalogenationsDiversity-oriented SynthesisTotal SynthesisPharmacologyBiomolecular EngineeringAlkene MetathesisNatural SciencesMedicineAromatic RingsDrug Discovery
Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin (1). Both routes make it possible to prepare 1 efficiently and in large quantity.