Synthetic studies on β-lactam antibiotics. Part 10. Synthesis of 7β-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7.alpha.-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-1-oxa-1-dethia-3-cephem-4-carboxylic acid disodium salt (6059-S) and its related 1-oxacephems

Masayuki Narisada, Tadashi Yoshida, Hiroshi Onoue, +6

Journal of Medicinal Chemistry

Medicinal ChemistryAntimicrobial Drug DiscoveryBioorganic Chemistryβ-Lactam AntibioticsBiochemistry +13

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Kenji Kawada, Akinori Arimura, Tatsuo Tsuri, +13

Angewandte Chemie International Edition

Proper LinkageImmunologyOrganic ChemistryChemistryHeterocycle Chemistry +15

Total Synthesis of Terprenin, a Novel Immunosuppressive <i>p</i>-Terphenyl Derivative

Shuji Yonezawa, Tadafumi Komurasaki, Kenji Kawada, +11

The Journal of Organic Chemistry

Medicinal ChemistryAntifungal AgentBioorganic ChemistryBiochemistryNatural Sciences +9

Synthesis of thromboxane receptor antagonists with bicyclo[3.1.0]hexane ring systems

Susumu Kamata, Nobuhiro Haga, Tatsuo Tsuri, +4

Journal of Medicinal Chemistry

ThrombopoiesisThrombosisHeterocyclicBiochemistryThromboxane Receptor +13

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects

Masanao Inagaki, Masaharu Kume, Yoshinori Tamura, +9

Bioorganic & Medicinal Chemistry Letters

Opioid EpidemicOpioid-induced Adverse EffectsPain MedicinePharmacologyOpioid Use Disorder +8

Aldosterone antagonists. 1. Synthesis and biological activities of 11.beta.,18-epoxypregnane derivatives

Susumu Kamata, Nobuhiro Haga, Takashi Mitsugi, +6

Journal of Medicinal Chemistry

PharmacotherapyGlucocorticoidPharmaceutical ChemistryAdrenal GlandStereoselective Synthesis +15

Aldosterone antagonists. 2. Synthesis and biological activities of 11,12-dehydropregnane derivatives

Susumu Kamata, Takeaki Matsui, Nobuhiro Haga, +6

Journal of Medicinal Chemistry

PharmacotherapyGlucocorticoidAdrenal GlandStereoselective SynthesisSteroid Metabolism +14

Highly <i>E</i>-Selective and Effective Synthesis of Antiarthritic Drug Candidate S-2474 Using Quinone Methide Derivatives

Masanao Inagaki, Nobuhiro Haga, Makoto Kobayashi, +3

The Journal of Organic Chemistry

Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

Sanji Hagishita, Kaoru Seno, Susumu Kamata, +4

Bioorganic & Medicinal Chemistry

Functional SelectivityMedicineMechanism Of ActionPharmacological AgentPharmacotherapy +3

A new practical tritium labelling procedure using sodium borotritide and tetrakis(triphenylphosphine)palladium(0)

T. Nagasaki, Katsunori Sakai, Masaharu Segawa, +5

Journal of Labelled Compounds and Radiopharmaceuticals

EngineeringOrganic ChemistryChemistryReagentPharmaceutical Chemistry +15