Journal of Medicinal Chemistry · 1990 · 22 citations · 0 references
MedicineMedicinal ChemistryPharmacologyDrug DesignMolecular PharmacologyStructure-activity RelationshipsPlatelet ActivationPlatelet AdhesionPlatelet AggregationPlatelet FunctionPlatelet PhysiologyStructure-activity Relationship AnalysisAdenosine Diphosphate-induced Platelet AggregationAntiplatelet DrugsArachidonic Acid SignalingPlatelet Aggregation InhibitionPlatelet InhibitionPlatelet Receptor-ligand InteractionsPlatelet Responses To AgonistsThrombotic Platelet Aggregation
Thromboxane A2 receptor antagonists 11a, 15a, 26a, 30a, 34a, 36a, 46a, 52a, 61a, 72a, and 82a, which contain 6-oxabicyclo[3.1.0]hexane, 6-thiabicyclo[3.1.0]hexane, bicyclo[3.1.0]hexane, or 6,6-dimethylbicyclo[3.1.0]hexane ring systems with heptenoic and (phenylsulfonyl)amino side chains, and their corresponding sodium salts and methyl esters were synthesized. This study then examined the inhibitory effects of their sodium salts for the platelet aggregation induced by arachidonic acid with rabbit platelet-rich plasma and platelet aggregation induced by collagen with rat washed platelets.