Total synthesis of discorhabdin C: a general aza spiro dienone formation from O-silylated phenol derivatives using a hypervalent iodine reagent

Yasuyuki Kita, Hirofumi Tohma, Masanao Inagaki, +2

Journal of the American Chemical Society

Derivative (Chemistry)Diversity Oriented SynthesisBioorganic ChemistryEngineeringO-silylated Phenol Derivatives +13

Hypervalent iodine oxidation of N-acyltyramines: synthesis of quinol ethers, spirohexadienones, and hexahydroindol-6-ones

Yasuyuki Kita, Hirofumi Tohma, Kazumi Kikuchi, +2

The Journal of Organic Chemistry

HalogenationChemical EngineeringEnantioselective SynthesisEngineeringHeterocyclic +10

Novel Antiarthritic Agents with 1,2-Isothiazolidine-1,1-dioxide (γ-Sultam) Skeleton: Cytokine Suppressive Dual Inhibitors of Cyclooxygenase-2 and 5-Lipoxygenase

Masanao Inagaki, Tatsuo Tsuri, Hirokuni Jyoyama, +13

Journal of Medicinal Chemistry

PharmacotherapyAntioxidant MoietyGamma-sultam SkeletonPharmaceutical ChemistryInflammatory Arthritis +15

A novel oxidative azidation of aromatic compounds with hypervalent iodine reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl azide

Yasuyuki Kita, Hirofumi Tohma, Masanao Inagaki, +2

Tetrahedron Letters

Chemical EngineeringEngineeringHeterocyclicAromatic CompoundsNovel Oxidative Azidation +6

Ezetimibe improves postprandial hyperlipidaemia in patients with type IIb hyperlipidaemia

Daisaku Masuda, Yumiko Nakagawa-Toyama, Kazuhiro Nakatani, +7

European Journal of Clinical Investigation

Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D₂ Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives

Susumu Mitsumori, Tatsuo Tsuri, Tsunetoshi Honma, +10

Journal of Medicinal Chemistry

PharmacotherapyChemical BiologyVarious DerivativesPharmaceutical ChemistryChemical Derivative +19

Discovery of S-777469: An orally available CB2 agonist as an antipruritic agent

Masahide Odan, Natsuki Ishizuka, Yoshiharu Hiramatsu, +9

Bioorganic & Medicinal Chemistry Letters

Functional SelectivityMedicineAvailable Cb2 AgonistMechanism Of ActionPharmacotherapy +3

Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant

Kenji Kawada, Akinori Arimura, Tatsuo Tsuri, +13

Angewandte Chemie International Edition

Proper LinkageImmunologyOrganic ChemistryChemistryHeterocycle Chemistry +15

Total Synthesis of Terprenin, a Novel Immunosuppressive <i>p</i>-Terphenyl Derivative

Shuji Yonezawa, Tadafumi Komurasaki, Kenji Kawada, +11

The Journal of Organic Chemistry

Medicinal ChemistryAntifungal AgentBioorganic ChemistryBiochemistryNatural Sciences +9

Hypervalent iodine oxidation of O-silylated phenol derivatives to azacarbocyclic spirodienones; synthetic approach to the anticancer marine alkaloid, discorhabdin C

Yasuyuki Kita, Hirofumi Tohma, Masanao Inagaki, +3

Tetrahedron Letters

Medicinal ChemistryDerivative (Chemistry)BiochemistryO-silylated Phenol DerivativesNatural Sciences +8