Microwave-assisted synthesis utilizing supported reagents: a rapid and versatile synthesis of 1,5-diarylpyrazoles

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 1.9K citations · Full text

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

Christopher Pargellis, Liang Tong, Laurie Churchill et al. · Nature Structural Biology · 2002 · 832 citations · Full text

Molecular Pharmacology, Drug Target, Molecular Physiology +11

Synthesis of pyrazoles

Kenzi Makino, Ho Sik Kim, Yoshihisa Kurasawa · Journal of Heterocyclic Chemistry · 1998 · 98 citations

Other Research Groups, Natural Sciences, Medicine +9

1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors

Jacques Dumas, Holia Hatoum‐Mokdad, Robert Sibley et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 53 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, 1-Phenyl-5-pyrazolyl Ureas +6

Microwave-Assisted Synthesis Utilizing Supported Reagents:  A Rapid and Efficient Acylation Procedure

Daryl R. Sauer, Douglas Kalvin, Kathleen M. Phelan · Organic Letters · 2003 · 51 citations

Materials Science, Microwave Synthesis, Engineering +15