Concepedia

<i>Kras</i>and<i>Lkb1</i>mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells

Louis Collet, Elsa Ghurburrun, Nora Meyers, Mohamad Assi, Boris Pirlot, Isabelle Leclercq, Anne Couvelard, Mina Komuta, Jérôme Cros, Pieter Demetter,

Gut · 2019 · 41 citations · 31 references

DOIFull text

Open access

Abstract

Our work demonstrates that IPMN can result from synergy between <i>Kras</i><sup>G12D</sup> mutation and inactivation of a tumour suppressor gene. The ductal epithelium can give rise to glandular neoplasms and papillary lesions, which probably both contribute to IPMN formation.

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