Concepedia

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

Tsz Ying Yuen, Christopher J. Brown, Yuezhen Xue, Yaw Sing Tan, Fernando Jose Ferrer Gago, Xue Er Lee, Jin Yong Neo, Dawn Thean, Hung Yi Kristal Kaan, Anthony W. Partridge,

Chemical Science · 2019 · 27 citations · 60 references

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Concepts

Abstract

Staple composition can influence target binding and bioactivity of peptides. We present strategies to modulate<italic>E</italic>/<italic>Z</italic>ratios and access saturated analogues.

References

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