Nature · 2007 · 2.4K citations · 25 references
MedicineCancer BiologyOncologyCarcinogenesisMolecular OncologyTumor ProgressionCancer ProgressionCellular SenescenceDna Damage-induced ApoptosisHepatocellular CarcinomaLiver CancerMalignant NeoplasmsCancer Cell SenescenceCell SenescenceP53 InactivationP53 MutationP53 Pathway InactivationTumor Suppression By SenescenceTumor Suppressor P53
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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text
Medicine, Cell Biology, Oncology +10
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations
Medicine, Oncology, Pharmacology +15
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text
Life Sciences, Biology, Cell Biology +12
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin et al. · Nature · 2007 · 1.8K citations