Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.6K citations

Tumor Biology, Small-molecule Antagonists, Mdm2-p53 Interaction +14

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Aging, Cell Division, Medicine +3

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

Cell Regulation, Pten-deficient Tumorigenesis, Crucial Role +10

Restoration of p53 function leads to tumour regression in vivo

Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin et al. · Nature · 2007 · 1.8K citations

P53 Function, Tumor Heterogeneity, Medicine +10