Science · 2019 · 236 citations · 14 references
EducationPharmacologyPharmacotherapyAgingApoptosisGerontologyAging PhysiologyBiological AgingCellular AgingCellular SenescenceHealthy AgingLongevityAge-related Tissue DysfunctionAging-related InflammationCell SenescenceSenescence DisordersSenescence-associated ApoptosisSenescence-associated Cell DeathSenolytic Therapy
Clearing senescent cells with targeted drugs could combat age-associated disease
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.6K citations · Full text
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text
Senolytics improve physical function and increase lifespan in old age
Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.2K citations
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Jianhui Chang, Yingying Wang, Lijian Shao et al. · Nature Medicine · 2015 · 1.8K citations