Concepedia

Age-related Tissue Dysfunction

Age-Related Tissue Dysfunction is a pathological condition characterized by the progressive decline in tissue homeostasis and function due to the accumulation of senescent cells and their associated secretory phenotype over time.

794

Publications

53.5K

Citations

4.2K

Authors

1.2K

Institutions

Publications per year

2017–2026

228

Parents

Publications

794

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco, Takahiro Ito, Anna P. Petrashen et al. · Nature · 2019 · 1.2K citations

, , +14

Decreased Collagen Production in Chronologically Aged Skin

James Varani, Michael K. Dame, Laure Rittié et al. · American Journal Of Pathology · 2006 · 864 citations · Full text

, , +13

‘Hormonal’ risk factors, ‘breast tissue age’ and the age-incidence of breast cancer

Malcolm C. Pike, Mark Krailo, Brian E. Henderson et al. · Nature · 1983 · 713 citations

, , +16

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dennis W. Dickson, Howard Crystal, Linda A. Mattiace et al. · Neurobiology of Aging · 1992 · 641 citations

, , +13

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

Helen Vlassara, Michael Brownlee, Kirk R. Manogue et al. · Science · 1988 · 604 citations

, , +17

1–5 of 794

Authors

4.2K

  1. JL
    James L. Kirkland

    Mayo Clinic in Florida, United States

    15 publications · 2.7K citations

    14

    h-index

  2. TT
    Tamar Tchkonia

    Mayo Clinic in Florida, United States

    14 publications · 2.6K citations

    14

    h-index

  3. NK
    Nathan K. LeBrasseur

    Mayo Clinic, United States

    10 publications · 2K citations

    10

    h-index

  4. LJ
    Laura J. Niedernhofer

    University of Pittsburgh, United States

    8 publications · 1.3K citations

    7

    h-index

  5. YZ
    Yi Zhu

    Mayo Clinic in Florida, United States

    7 publications · 1.5K citations

    7

    h-index

1–5 of 4.2K

Institutions

1.2K

  1. Mayo Clinic in Florida

    Jacksonville, United States

    21 h-index

    175 publications

    31.5K citations

  2. Mayo Clinic

    Rochester, United States

    17 h-index

    87 publications

    9.4K citations

  3. University of Washington

    Seattle, United States

    17 h-index

    90 publications

    4.1K citations

  4. University of Michigan

    Ann Arbor, United States

    17 h-index

    78 publications

    12.2K citations

  5. National Institute on Aging

    Baltimore, United States

    16 h-index

    61 publications

    4.1K citations

  6. National Institutes of Health

    Bethesda, United States

    15 h-index

    58 publications

    5.7K citations

  7. Johns Hopkins University

    Baltimore, United States

    14 h-index

    61 publications

    6.1K citations

  8. University College London

    London, United Kingdom

    13 h-index

    43 publications

    3K citations

1–8 of 1.2K

Venues

  1. PubMed

    Repository · 40 publications · 1.5K citations

    25

    h-index

  2. Journal of Gerontology

    40 publications · 2.3K citations

    24

    h-index

  3. Experimental Gerontology

    30 publications · 1.3K citations

    21

    h-index

  4. Mechanisms of Ageing and Development

    30 publications · 1.9K citations

    20

    h-index

  5. Aging Cell

    20 publications · 1.3K citations

    18

    h-index

1–5