Laura J. Niedernhofer

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.3K citations · Full text

Apoptosis, Immunology, Immune Regulation +18

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.1K citations · Full text

Lifespan Extension, Allergy, Anti-aging +10

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Yi Zhu, Tamar Tchkonia, Heike Fuhrmann‐Stroissnigg et al. · Aging Cell · 2015 · 1.1K citations · Full text

Apoptosis, Immunology, Cell Death +17

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan et al. · EBioMedicine · 2018 · 913 citations · Full text

An aged immune system drives senescence and ageing of solid organs

Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu et al. · Nature · 2021 · 881 citations · Full text

Inflammation, Autoimmune Disease, Anti-aging +11