The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava, +30

Aging Cell

ApoptosisImmunologyImmune RegulationCell DeathImmunotherapeutics +16

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, +29

Nature Medicine

Lifespan ExtensionAllergyAnti-agingAgingLongevity +8

Cellular senescence mediates fibrotic pulmonary disease

Marissa J. Schafer, Thomas A. White, Koji Iijima, +20

Nature Communications

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart, +30

EBioMedicine

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr, Ming Xu, Megan Weivoda, +15

Nature Medicine

Anti-agingAgingLongevityCellular SenescenceBiogerontology +3

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Yi Zhu, Tamar Tchkonia, Heike Fuhrmann‐Stroissnigg, +11

Aging Cell

ApoptosisImmunologyCell DeathPharmacotherapyCancer Biology +15

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, +19

EBioMedicine

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu, Tamar Tchkonia, Husheng Ding, +11

Proceedings of the National Academy of Sciences

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Carolyn M Roos, Bin Zhang, Allyson K. Palmer, +12

Aging Cell

Vascular DiseaseAgingImmunologyNitric Oxide BioavailabilitySenolytic Treatment +16

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Yi Zhu, Ewald J. Doornebal, Tamar Pirtskhalava, +7

Aging