Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, +29

Nature Medicine

Lifespan ExtensionAllergyAnti-agingAgingLongevity +8

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr, Ming Xu, Megan Weivoda, +15

Nature Medicine

Anti-agingAgingLongevityCellular SenescenceBiogerontology +3

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, +19

EBioMedicine

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu, Tamar Tchkonia, Husheng Ding, +11

Proceedings of the National Academy of Sciences

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

Allyson K. Palmer, Ming Xu, Yi Zhu, +30

Aging Cell

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Ming Xu, Allyson K. Palmer, Husheng Ding, +11

eLife

Old AgeMetabolic RemodelingActivin AAdipokinesInsulin Signaling +15

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Mikołaj Ogrodnik, Yi Zhu, Tamar Tchkonia, +20

Cell Metabolism

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

Laura L. Dugan, Young-Hyun You, Sameh S. Ali, +18

Journal of Clinical Investigation

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Ming Xu, Elizabeth W. Bradley, Megan Weivoda, +11

The Journals of Gerontology Series A

InflammationTissue EngineeringRheumatoid DisorderBone Morphogenic ProteinIn Vivo System +11

Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes

Gang Ye, Naira Metreveli, Rajakumar V. Donthi, +4

Diabetes

Antioxidant GenesCardiac MuscleHeart FailureReactive Oxygen SpeciesRedox Biology +17