L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco, Takahiro Ito, Anna P. Petrashen, +18

Nature

InflammationCytokineImmunologyChronic InflammationCell Death +6

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Matthew Simon, Michael Van Meter, Julia Ablaeva, +17

Cell Metabolism

InflammationLifespan ExtensionAutoimmune DiseaseImmune Cell DevelopmentImmunology +9

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Marco De Cecco, Steven W. Criscione, Edward Peckham, +7

Aging Cell

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

Marco De Cecco, Steven W. Criscione, Abigail L. Peterson, +3

Aging

Knockout MouseChromatinTransgenerational EffectDevelopmental BiologyActive Transposition +13

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Claudia C.S. Chini, Thais Peclat, Gina M. Warner, +29

Nature Metabolism

InflammationImmune CellsNmn LevelsBiochemistryCd38 Ecto-enzyme +9

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

Jeffrey W. Hofmann, Xiaoai Zhao, Marco De Cecco, +17

Cell

Lifespan ExtensionLongevityPhysiologyCellular SenescenceMyc Increases Longevity

Reorganization of chromosome architecture in replicative cellular senescence

Steven W. Criscione, Marco De Cecco, Benjamin A. Siranosian, +4

Science Advances

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, +21

The Journals of Gerontology Series A

JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response

Benedetta Assetta, Marco De Cecco, Bethany A. O’Hara, +1

mBio

Death by transposition – the enemy within?

John M. Sedivy, Jill A. Kreiling, Nicola Neretti, +6

BioEssays

AgingGeneticsEpigeneticsTransgenerational EffectThanatology +15