Matthew Simon

L1 drives IFN in senescent cells and promotes age-associated inflammation

Marco De Cecco, Takahiro Ito, Anna P. Petrashen et al. · Nature · 2019 · 1.2K citations

Inflammation, Cytokine, Immunology +8

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Matthew Simon, Michael Van Meter, Julia Ablaeva et al. · Cell Metabolism · 2019 · 473 citations · Full text

Inflammation, Lifespan Extension, Autoimmune Disease +11

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Xiao Tian, Denis Firsanov, Zhihui Zhang et al. · Cell · 2019 · 348 citations · Full text

Chromatin, Genome Instability, Dna Damage +9

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks

Michael Van Meter, Matthew Simon, Gregory Tombline et al. · Cell Reports · 2016 · 125 citations · Full text

<i>Drosophila</i>Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

Wilson Leung, C. Shaffer, Laura K Reed et al. · G3 Genes Genomes Genetics · 2015 · 100 citations · Full text